Analysis of the Density Characteristics of Giant Cell Bone Tumors Treated with Denosumab According to CT Findings

Background: Giant cell tumor of bone (GCTB) is a relatively common benign tumor, accounting for 4–9.5 % all primary neoplasms. Localization GCTB one the most important differential diagnostic criteria, since affects certain parts skeleton. Until now, surgical treatment was considered method choice in GCTB. However, recent years, denosumab, genetically engineered drug, has been widely used to treat this tumor. Denosumab prevents further progression and reduces size. Histological examination specimen undoubtedly objective assessing effectiveness treatment. it sometimes necessary get information regarding conservative therapy. Purpose : To analyze density characteristics denosumab-treated using CT densitometry. Material methods The study included 15 patients aged 28–59 years with histologically verified giantcell who received denosumab followed by surgery. Tumor structure assessed before starting therapy, after 3 6 courses Results Changes parameters (the mean density, standard deviation increase median index relative tumor) measured images were analyzed. These changes statistically significant initiating therapy Conclusion Thus, densitometry useful tool GCS treated denosumab.